50
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8239 |
Cromoglicic acid
|
Others | Others |
Cromoglicic acid 可防止肥大细胞释放炎性化学物质,例如组胺。 | |||
T0211 |
Azelastine
Azelastina,Astelin,Azelastinum,氮卓斯汀 |
SARS-CoV; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Azelastine (Azelastinum) 是一种选择性组胺 1 拮抗剂,可研究过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 。 | |||
T3979 |
Emedastine
LY188695,依美斯汀,Emadine |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Emedastine (LY188695) 是一种可口服的,选择性和高亲和力的组胺 H1受体拮抗剂,Ki 值为 1.3 nM。它是苯并咪唑衍生物,可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。 | |||
T0118 |
Mizolastine
SL 850324,咪唑司汀,咪唑斯汀 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Mizolastine (SL 850324) 是组胺 H1 受体拮抗剂,IC50为 47 nM。它用于治疗过敏反应,如花粉热和荨麻疹等。 | |||
T21404 |
Fluticasone furoate
Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate |
Glucocorticoid Receptor | Endocrinology/Hormones |
Fluticasone furoate (Avamys) 是一种合成的三氟化皮质类固醇,衍生自氟替卡松,Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。 | |||
T6242 |
Rupatadine Fumarate
富马酸卢帕他定,Rinialer,Rupafin,Alergoliber |
PAFR; Autophagy; Histamine Receptor | Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Rupatadine Fumarate (Rinialer) 是一种可口服的长效PAF/H1受体的双抑制剂,Ki 值分别为 0.55 μM 和 0.1 μM。它可研究过敏性鼻炎和荨麻疹。 | |||
T0059 |
Diphenylpyraline hydrochloride
盐酸双苯比拉林,4-Diphenylmethoxy-1-methylpiperidine hydrochloride |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) 是一种组胺 H1 受体的拮抗剂,抑制多巴胺的吸收。它是可口服的抗组胺试剂,具有抗胆碱和抗过敏作用,可用于缓解过敏性疾病,如鼻炎、花粉热和瘙痒性皮肤疾病等。 | |||
T3185 |
R112
(E)-Elafibranor |
Syk | Angiogenesis; Tyrosine Kinase/Adaptors |
R112 ((E)-Elafibranor) 是ATP 竞争性的 Syk 激酶抑制剂,它能够抑制Syk 激酶活性,Ki=6 nM,IC50=226 nM。 | |||
T0211L |
Azelastine hydrochloride
Optivar,Azelastine HCl,Allergodil,盐酸氮卓斯汀,Astelin |
SARS-CoV; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Azelastine hydrochloride (Astelin) 是一种选择性组胺 1拮抗剂,可研究过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 。 | |||
T1030 |
Triprolidine hydrochloride monohydrate
盐酸曲普利啶,盐酸曲普利啶一水合物,Triprolidine hydrochloride |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Triprolidine hydrochloride monohydrate 是一种组胺 H1 拮抗剂,用于过敏性鼻炎、哮喘。 | |||
T1269 |
Tripelennamine hydrochloride
Pyribenzamine hydrochloride,去敏灵,Tripelennamine HCl,Pyribenzamine HCl,盐酸曲吡那敏 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Tripelennamine hydrochloride (Pyribenzamine hydrochloride) 是一种组胺 H1 拮抗剂,具有低镇静作用,但经常刺激胃肠道。 | |||
T2335 |
Ebastine
Ebastel,依巴斯汀,LAS-W 090,Ebastin,Kestine,RP64305 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Ebastine (Kestine) 是一种可口服的组胺 H1 受体拮抗剂,用于过敏性鼻炎的症状和慢性特发性荨麻疹的研究。 | |||
T0188 |
Fluticasone (propionate)
丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate |
Glucocorticoid Receptor; Virus Protease; Estrogen/progestogen Receptor; Phospholipase; Endogenous Metabolite | Endocrinology/Hormones; Metabolism; Microbiology/Virology |
Fluticasone propionate (CCI-187881) 是一种选择性糖皮质激素受体激动剂,是一种局部抗炎激素,亲和力KD 为 0.5 nM。具有抗病毒活性。 | |||
T0205 |
Brompheniramine maleate
Dimotane,马来酸溴苯那敏,Rolabromophen,Brompheniramine hydrogen maleate,Dimetane |
5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Brompheniramine maleate (Dimotane) 是一种可口服的丙胺类抗组胺剂,具有抗胆碱能和抗抑郁作用,可用于过敏性鼻炎和缓解疼痛的研究。它是一种选择性组胺 H1 受体拮抗剂,Kd 为 6.06 nM。 | |||
T0089 |
Cetirizine dihydrochloride
盐酸西替利嗪,P071,UCB P071,Cetirizine DiHCl |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Cetirizine dihydrochloride (UCB P071) 是羟嗪的羧化代谢物,是特异性口服有效的 H1 受体长效拮抗剂。它标记抗过敏特性,抑制过敏反应期间嗜酸性粒细胞趋化,可有效治疗过敏性鼻炎、确诊荨麻疹和花粉诱发的哮喘。 | |||
T6660 |
SB-705498
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
SB705498 是一种口服有效的 TRPV1选择性拮抗剂,pIC50值为 7.1。 | |||
T1553 |
Chlorpheniramine maleate
马来酸氯苯那敏,NCI-C55265,Chlorphenamine maleate |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Chlorpheniramine maleate (NCI-C55265) 是一种组胺 H1 拮抗剂,IC50为12 nM,用于过敏反应、花粉热、鼻炎、荨麻疹和哮喘。 | |||
T1531 |
Mometasone furoate
糠酸莫美他松,糠酸莫米松,Sch32088 |
Glucocorticoid Receptor | Endocrinology/Hormones |
Mometasone furoate (Sch32088) 是糖皮质激素受体激动剂,具有抗炎和抗过敏作用。它是皮质固醇类试剂,动物模型中,可局部应用于气道炎症、慢性皮肤湿疹、哮喘。 | |||
T2270 |
Trans-Tranilast
Tranilast trans-,反式-曲尼司特,反-曲尼司特 |
RAAS | Endocrinology/Hormones |
Trans-Tranilast 是抗过敏剂,可用于过敏性鼻炎、支气管哮喘和特应性皮炎的研究。 | |||
T1278 |
Astemizole
Laridal,Histaminos,Paralergin,阿司咪唑 |
Potassium Channel; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Astemizole (Laridal) 是一种长效、非镇静抗组胺药,用于治疗季节性过敏性鼻炎、哮喘、过敏性结膜炎和慢性特发性荨麻疹。它是组胺 H1 受体的拮抗剂,IC50值为 4 nM,还阻断 hERG K+通道,IC50值为 0.9 nM,具有抗胆碱能和止痒作用。 | |||
T2396 |
Ramatroban
BAY u3405,雷马曲班 |
GPR; Prostaglandin Receptor; PPAR | DNA Damage/DNA Repair; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism |
Ramatroban (BAY u3405) 是一种血栓素 A(2) (TxA(2)) 拮抗剂,IC50为 14 nM。它还通过抑制PGD2结合从而拮抗CRTH2,IC50为113 nM。它用于治疗过敏性鼻炎,可用于治疗哮喘的研究。 | |||
T77426 |
Pascolizumab
SB-240683 |
IL Receptor | Immunology/Inflammation |
Pascolizumab (SB-240683) 是一种人源化抗 IL-4 单克隆抗体。Pascolizumab 具有哮喘作用,可用于研究过敏性鼻炎。 | |||
T1470 |
Fexofenadine hydrochloride
Terfenidine carboxylate hydrochloride,MDL-16455 hydrochloride,盐酸非索非那定,Telfast,Fexofenadine HCl,Allegra,MDL 16455A |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Fexofenadine hydrochloride (Terfenidine carboxylate hydrochloride) 是一种抗组胺药,用于治疗过敏性鼻炎、血管性水肿和慢性荨麻疹。 | |||
T22354 |
Levocetirizine Dihydrochloride
Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria. | |||
T1097 |
Loratadine
氯雷他定,SCH 29851,Loratidine |
Influenza Virus; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Loratadine (SCH 29851) 是一种组胺 H1受体反向激动剂,IC50>32 μM。它抑制炎症介质的免疫释放,具有抗登革热病毒的活性。 | |||
T61213 |
PF-03654764
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
PF-03654764 是一种具有口服活性、高效性和选择性的组胺 H3 受体拮抗剂,对人 H3 和大鼠 H3 具有抑制作用, Ki 值分别为 1.2 nM 和 7.9 nM。PF-03654764 常与 Fexofenadine 一起联合用药来治疗过敏性鼻炎。 | |||
T2392 |
Nafamostat mesylate
甲磺酸萘莫司他,FUT-175 |
Apoptosis; Serine/threonin kinase; SARS-CoV; Serine Protease | Apoptosis; Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Nafamostat mesylate (FUT-175) 是一种广谱丝氨酸蛋白酶抑制剂,血管舒缓素抑制剂,能抑制血液凝固。它通过降低颗粒酶活性和 CTL 细胞溶解抑制T 细胞自身反应活性,可抑制SARS-CoV-2 的激活。它还是潜在的补体抑制剂。 | |||
T4563 |
Thonzylamine
neohetramine,松齐拉敏 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Thonzylamine (neohetramine) 是可口服的H1组胺受体拮抗剂,具有抗组胺和抗过敏特性,可用于鼻充血、过敏性结膜炎和其他过敏性疾病的研究。 | |||
T21112 |
Triprolidine hydrochloride
295 C 51,Pro-Entra,Entra,盐酸曲普利啶,Actidilat,Triprolidine hydrochloride anhydrous,Actidil,Pro-Actidil |
||
Triprolidine hydrochloride anhydrous, a Histamine H1 antagonist, is used in asthma, allergic rhinitis, and urticaria. | |||
T10437 |
AZD8848
|
TLR | Immunology/Inflammation |
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis. | |||
T69737 |
SCH-79687
|
||
SCH-79687 is a histamine antagonist selective for the H3 subtype. This H3 antagonist may play a role in allergic rhinitis. | |||
T29951 | Ambicromil | ||
Ambicromil is used for allergic rhinitis. | |||
T0785L |
Dexchlorpheniramine free base
Polaramine,Dexchlorpheniramine Maleate,Mylaramine |
||
Dexchlorpheniramine Maleate, a histamine receptor antagonist, is used to treat urticaria, allergic rhinitis, allergic conjunctivitis and pruritus. | |||
T27556 |
HSR-609
HSR609,FY609,FY-609,FY 609 |
||
HSR-609, a histamine H1 receptor antagonist, is used potentially for the treatment of allergic rhinitis. | |||
T27445 |
GSK-1004723
GSK 1004723 |
||
GSK-1004723 is a novel antagonist of histamine H(1) and H(3) receptor. It represents a potential novel therapy for allergic rhinitis. | |||
T37386 |
Dihydro Montelukast
|
||
Dihydro montelukast is a potential impurity found in commercial montelukast preparations. Montelukast (sodium salt) is a potent and selective cysteinyl leukotriene 1 (CysLT1) receptor antagonist. Formulations containing montelukast are used for the treatment of asthma as well as for the symptoms associated with allergic rhinitis. | |||
T21247 |
Carbinoxamine
Allergefon,(+-)-Carbinoxamine,Paracarbinoxamine |
||
Carbinoxamine, an anticholinergic and antihistamine agent, is used for hay fever, angioedema, vasomotor rhinitis, mild urticaria, dermatographism and allergic conjunctivitis. It is a histamine antagonist, specifically an H1-antagonist. | |||
T74646 | PM-81I | ||
PM-81I为一种高效STAT6抑制剂(针对SH2结构域),可显著减少STAT6的磷酸化水平。适用于研究过敏性肺病、过敏性鼻炎、慢性阻塞性肺病或癌症。 | |||
T26770 |
Bencycloquidium Bromide
BCQB |
||
Bencycloquidium Bromide is a muscarinic M3 antagonist. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. Bencycloquidium Bromide showed high affinity toward the M(3) receptor in Chinese hamster ovary (CHO) cells (M | |||
T16476 |
PF-03654746
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
PF-03654746 是组胺 H3 受体的选择性拮抗剂。 PF-03654746 提高了阿尔茨海默病的认知功效和疾病改善作用。 PF-03654746 可用于治疗过敏性鼻炎的研究。 | |||
T73972 | Fexofenadine Impurity F | ||
Fexofenadine Impurity F 是 Fexofenadine 的杂质。 Fexofenadine 是一种H1R 拮抗剂,可用于研究季节性过敏性鼻炎和慢性特发性荨麻疹。 | |||
T60514 |
Triprolidine
|
||
Triprolidine 是一种口服活性的组胺H1受体拮抗剂,可用于过敏性鼻炎的研究 。Triprolidine 具有脊髓运动和知觉阻止的作用。 | |||
T62669 |
Tripelennamine citrate
|
||
Tripelennamine citrate 是一种乙二胺衍生物,是一种有效的组胺 H1 受体拮抗剂。Tripelennamine citrate 能够减少组织胺引起的机体过敏反应。Tripelennamine citrate 能够用于研究鼻炎、结膜炎、过敏性和过敏性反应。 | |||
T73129 |
STAT6-IN-1
|
||
STAT6-IN-1(化合物19a)是一种针对STAT6的SH2结构域表现出较高亲和力(IC50=0.028 µM)的STAT6抑制剂。该化合物主要用于研究过敏性肺病、过敏性鼻炎、慢性阻塞性肺病或癌症。 | |||
T60392 |
Tripelennamine
|
||
Tripelennamine 是一种乙二胺衍生物,是一种有效的组胺 H1受体拮抗剂,可减轻由组织胺引起的机体过敏反应。Tripelennamine 可用于鼻炎、结膜炎、过敏性和过敏性反应的研究。 | |||
T68280 | Adriforant | ||
Adriforant, also known as ZPL-3893787, PF-3893787 and ZPL-389, is a novel histamine H4 receptor antagonist. Adriforant shows an excellent in vitro profile that warrants their further investigation in relevant models of human disease. Histamine H4 receptor (H4R) has become a promising target for immuno-inflammatory diseases, such as allergic rhinitis, asthma or dermal allergies. | |||
T38350 |
TAS 205
|
||
TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sens... | |||
T69918 |
Adriforant tartrate hydrate
|
||
Adriforant, also known as ZPL-3893787, PF-3893787 and ZPL-389, is a novel histamine H4 receptor antagonist. Adriforant shows an excellent in vitro profile that warrants their further investigation in relevant models of human disease. Histamine H4 receptor (H4R) has become a promising target for immuno-inflammatory diseases, such as allergic rhinitis, asthma or dermal allergies. | |||
T60843 |
Brompheniramine
|
||
Brompheniramine ((±)-Brompheniramine) 是具有口服活性的烷基胺类抗组胺药。Brompheniramine 是组胺 H1 受体的选择性拮抗剂 (Kd = 6.06 nM)。Brompheniramine 可用于过敏性鼻炎,它具有抗胆碱能、抗抑郁和麻醉作用。Brompheniramine 可阻断钙离子通道、钠离子通道和 hERG 通道,IC50分别为 16.12 μM, 21.26 μM 和 0.90 μM。 | |||
T74583 |
Desmethylazelastine
|
||
Desmethylazelastine是Azelastine经由细胞色素P450酶系统的氧化代谢形成的主要活性代谢物,具有97%的蛋白结合率和54小时的消除半衰期。Azelastine作为一种口服活性的组胺H1受体拮抗剂,特点是选择性高和亲和力强。它主要用于治疗过敏性鼻炎、哮喘、糖尿病高脂血症以及用于SARS-CoV-2的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4S0878 |
Prunetin
樱黄素,Prunusetin |
ERK; Dehydrogenase; NF-κB | MAPK; Metabolism; NF-κB |
Prunetin (Prunusetin) 是一种O-甲基化异黄酮,具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。 | |||
T4038 |
Ectoine
THP(B),L-Ectoine,四氢甲基嘧啶羧酸 |
Others; Antibacterial | Microbiology/Virology; Others |
Ectoine (L-Ectoine) 是生活在极其恶劣环境中的细菌所产生的氨基酸衍生物,是一种天然的细胞保护剂。它具有良好的安全性,可研究过敏性鼻炎。它用作渗透调节相容性溶质,可增加皮肤表面的水合作用并稳定脂质层,常用于皮肤护理。 |